New laboratory analysis in Avicena Laboratory

Dears,

We would like to inform you that PHI Avicena Laboratory expand its test menu with the following laboratory diagnostic tests:

INVASIVE CANDIDIASIS (CAGTA) VIRCLIA® IgG MONOTEST

The test is designed to detect Candida in immunosuppressed patients, Intensive care unit (ICU) patients, patients on chemotherapy, patients with AIDS, after treatment with broad-spectrum antibiotics etc. This unique test is the only one in our country that detects invasive candidiasis in blood or serum with highly sensitive and specific chemiluminescent method and can make differentiation between invasive candidiasis or colonization. Unlike conventional methods where the detection of Candida takes up to 2 weeks, this method is faster –24 hours are only needed.

HERPES SIMPLEX 1+2 VIRCLIA® IgM MONOTEST

The test used to detect primary herpes simplex virus (HSV) infections. HSV 1 and HSV 2 are the two most medically significant types. The most common manifestation of HSV 1 infections is gingivostomatitis, conjunctivitis, keratitis, but there are also known cases of severe pharyngitis and encephalitis. HSV 2 is the most common cause of genital ulcers and as a consequence may lead to neonatal aseptic meningitis. This test is using highly sensitive and specific chemiluminescence method which detects IgM antibodies even if there is no visible change in the mucous membrane.

PARVOVIRUS VIRCLIA® IgM MONOTEST

The test detects Parvovirus B19 . In the childhood, 50% of the population is infected with this virus as an mild disease with erythema which occurs most often on the cheeks (so-called the fifth disease). Parvovirus B19 in adults usually manifests as arthritis without rash. The most important complication of Parvovirus B19 occurs during pregnancy. Because the virus crosses the placenta and infect the fetus, it can cause fetal hydrops and death, especially in the first half of pregnancy. The virus is transmitted from human to human at an early stage, before the onset of symptoms, with incubation period of 4-21 days. Parvovirus B19 can’t be cultivated and therefore the infection can be proved by serological methods in the acute phase of the disease. IgM antibodies can be detected 7-10 days after infection and may remain elevated for up to 3 months after infection. This test is highly sensitive and specific and use chemiluminescent methods for detection of IgM antibody early in the acute phase of the disease.

VARICELLA-ZOSTER VIRCLIA® IgM MONOTEST

The Varicella-Zoster Virus belongs to the herpesviruses and causes two diseases, chickenpox (varicella) in children and adolescents and herpes zoster in adults. Varicella is a febrile disease with generalized vesicular rash and after the recovery, the virus can remain latent for decades. If there is reactivation (especially in immunocompromised and elderly people) the lesions are unilateral and localized on dermatomes. During primary infection symptoms appear after 10-21 days of incubation. IgM detection is essential for proving varicella, often as in herpes zoster. Methods like this which are based on proving of glycoproteins are particularly sensitive in vaccinated patients. Highly sensitive and specific chemiluminescence method detects IgM antibodies before the appearance of the characteristic rash of the virus.

Note: The tests are run from serum or plasma. After taking samples, they should be kept at a temperature 2-8 ℃ to 7 days. Hyperlipemic, hemolyzed or contaminated samples are not tested.