VERAgene – The newest generation of non-invasive prenatal test

VERAgene is the only non-invasive prenatal test that performs simultaneous screening for aneuploidy, microdeletions and 100 monogenetic diseases.
Monogenetic diseases tested by VERAgene are associated with moderate to severe phenotype and have a significant impact on quality of life.
With screening for aneuploidy and microdeletions and 100 monogenetic diseases, VERAgene provides a comprehensive solution for potential parents.

WHAT IS A NON-INVASIVE PRENATAL TEST (NIPT)?
Non-invasive prenatal tests are tests that are performed by taking a blood sample from the mother to screen for the most common chromosomal abnormalities in the fetus during pregnancy.

WHAT ARE GENETIC DISORDERS?
Genetic disorders are caused by unwanted changes in the genome that occur during conception. The test detects three types of genetic conditions:

• Aneuploidies are genetic conditions that occur when there is an extra copy (trisomy) on the chromosome or when it lacks a copy (monosomy)
• microdeletions are genetic conditions caused by a small deletion in a certain region of the chromosome
• Monogenetic diseases

KEY FEATURES FOR VERAgene:
✅Can be done from the 10th week of pregnancy
✅Validated for single and twin pregnancies
✅Validated for IVF pregnancies
✅The only test on the market that includes a sample of both parents for screening for aneuploidy, microdeletions and 100 monogenetic diseases

HOW IS THE VERAgene TEST MADE?

During pregnancy, fetal cfDNA crosses the placenta and circulates in the mother’s blood, along with her own DNA. Fetal cfDNA is isolated from maternal blood and analyzed independently for aneuploidy and microdeletions, along with paternal DNA to detect potential genetic mutations in parents, using a new generation of its own technology and bioinformatics analysis.

WHAT DISORDERS ARE DETECTED BY THE VERAgene TEST?

• ANNEUPLOIDS
  Down Syndrome (Trisomy 21)
  Edwards Syndrome (Trisomy 18)
  Patau syndrome (Trisomy 13)

• SEXUAL CHROMOSOMES ANNEOPLOIDS
  Turner syndrome (Monosomy X)
  Triple X-syndrome (Trisomy X)
  Klinefelter syndrome (XXY)
  Jacobs Syndrome (XYY)
  XXYY syndrome

• MICRODELECIES
  DiGeorge syndrome (22q11.2)
  1p36 deletion syndrome (1p36)
  Smith-Magenis syndrome (17p11.2)
  Wolf-Hirschhorn syndrome (4p16.3)
  MONOGENETIC DISEASES
  A panel of 100 autosomal and X-linked monogenetically
  diseases, including:
  Cystic fibrosis
  Sickle cell disease
  Beta-thalassemia
  Tay-Sachs disease
  Gaucher’s disease
  Phenylketonuria
  Autosomal recessive polycystic kidney disease
  Canavan’s disease
  Fanconi anemia, Type C
  Usher syndrome, Type 1F
  Myotubular myopathy
  See the full list of 100 monogenetic diseases here.

• DETERMINING THE GENDER OF THE BABY

IS THERE AN ADULT LIMIT FOR VERAgene?
No. VERAgene can be done by pregnant women of all ages because it checks for genetic conditions that pose no risk to the mother’s age
WHEN CAN I TAKE THE TEST?
The VERAgene test can be done as early as the 10th week of gestation.

WHY SHOULD PROSECUTIVE PARENTS TAKE THE VERAgene TEST?
Microdiagnosis and monogenetic diseases – unlike aneuploidies – have no risk associated with maternal age, and for most there are no biochemical or ultrasound biomarkers that can aid in early detection.
The cumulative risk of the fetus being affected by one of the monogenetic diseases detected by VERAgene is 1 in 50 in moderate to high risk pregnancies and may be higher in some ethnic populations where some of the conditions are more common.

HOW CAN I TAKE THE VERAgene TEST?
The test can be done by any pregnant woman starting from the tenth gestational week of pregnancy.
Samples for the VERAgene test are taken only at the Avicenna Laboratory (sample venous blood from the mother and oral swab from the biological father).
Consult your doctor about VERAgene.
Visit our lab for more detailed test information or ask us at 02 3179 001 to talk to our VERACITY representative.
You can pick up the results in person from Avicenna Laboratory in 5-7 working days.
Test price: 37 900 denars

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